Developing a Conceptual Model of Cultural Policy-making in District 8 Payame Noor Universities based on Piety

The present study aimed to provide a conceptual model of cultural policy-making in Payame Noor universities in District 8 based on piety and virtue. In this study, the components of cultural policy based on piety were first identified through exploratory studies and surveys of knowledge-aware experts using the Delphi technique, and then these factors were tested in the form of a model designed in the statistical population. The statistical population of the study was 30 experts to test the model and to measure the research variables according to the managers of District 8 Payame Noor University; the head of cultural affairs of the university and clerics and professors of Islamic education department of Payame Noor Universities District 8 were used, which were 110 individuals. Due to the limited statistical population, the census method was used. The present study is a descriptive-correlational research that has been done by survey method. Furthermore, this research is development-applied in terms of purpose. The data collection method in this study is a combination of library and field studies and the tools of data collection are review of documents, interviews and questionnaires, which confirmed the validity and reliability of the questionnaires. In order to analyze the data, descriptive statistics (types of indicators, statistical tables and graphs) and inferential statistics (structural equation modeling) have been used. The research findings, while confirming the proposed model of research, showed that piety and its components: God-centeredness and monotheism, promoting the need to obey divine sovereignty, expediency in Islamic culture and meritocracy (Imam Ali's biography) have a positive and significant effect on cultural planning. At the end, research suggestions were presented

Active-passive Immunization Effectiveness Against Hepatitis B Virus in Children Born to HBsAg Positive Mothers in Amol, North of Iran

Objectives: HBV infection is a contagious disease that may transmit vertically from mothers to their neonates or horizontally by blood products and body secretions. Over 50% of Iranian carriers have contracted the infection perinatally, making this the most likely route of transmission of HBV in Iran. Tis study assesses the serologic markers of HBV in children born to HBsAg positive mothers who received HBIG and 3 doses of HBV vaccine. Methods: To evaluate the effectiveness of vaccination against HBV, a study was conducted on 95 Children, born to hepatitis B surface antigen (HBsAg)-positive mothers, who had received Hepatitis B Immune Globulin and HBV vaccines during 2004- 2008. All children were tested for the presence of HBsAg, antiHBs and anti-HB core antigen (anti-HBc). Results: Among an estimated 30000 pregnant women during the fve year study, about 130 (0.42%) were HBV carriers. Ninety-fve children from these mothers were enrolled in this study. Only one child (1.1%) was HBsAg positive, while 88.4% of children were Anti-HBs Positive. Eleven children (11.6%) were exposed to HBV as shown by the presence of anti-HBc. A signifcant difference was observed between the children’s age and Anti-HBs (p=0.0001). Conclusion: Passive-active immunoprophylaxis of high risk babies was highly efcacious in preventing perinatal transmission of the HBV carrier state. Also, evaluation of serologic markers in HBV infected people is important for designing the strategies for disease control

Relationship between ureB Sequence Diversity, Urease Activity and Genotypic Variations of Different Helicobacter pylori Strains in Patients with Gastric Disorders

Association of the severity of Helicobacter pylori induced diseases with virulence entity of the colonized strains was proven in some studies. Urease has been demonstrated as a potent virulence factor for H. pylori. The main aim of this study was investigation of the relationships of ureB sequence diversity, urease activity and virulence genotypes of different H. pylori strains with histopathological changes of gastric tissue in infected patients suffering from different gastric disorders. Analysis of the virulence genotypes in the isolated strains indicated significant associations between the presence of severe active gastritis and cagA+ (P = 0.039) or cagA/iceA1 genotypes (P = 0.026), and intestinal metaplasia and vacA m1 (P = 0.008) or vacA s1/m2 (P = 0.001) genotypes. Our results showed a 2.4-fold increased risk of peptic ulcer (95% CI: 0.483–11.93), compared with gastritis, in the infected patients who had dupA positive strains; however this association was not statistically significant. The results of urease activity showed a significant mean difference between the isolated strains from patients with PUD and NUD (P = 0.034). This activity was relatively higher among patients with intestinal metaplasia. Also a significant associa­tion was found between the lack of cagA and increased urease activity among the isolated strains (P = 0.036). While the greatest sequencevariation of ureB was detected in a strain from a patient with intestinal metaplasia, the sole determined amino acid change in UreB sequence (Ala201Thr, 30%), showed no influence on urease activity. In conclusion, the supposed role of H. pylori urease to form peptic ulcer and advancing of intestinal metaplasia was postulated in this study. Higher urease activity in the colonizing H. pylori strains that present specific virulence factors was indicated as a risk factor for promotion of histopathological changes of gastric tissue that advance gastric malignancy

The Role of DNA Viruses in Human Cancer

This review discusses the possible involvement of infections-associated cancers in humans, with virus infections contributing 15% to 20% of total cancer cases in humans. DNA virus encoded proteins interact with host cellular signaling pathways and control proliferation, cell death and genomic integrity viral oncoproteins are known to bind cellular Deubiquitinates (DUBs) such as cyclindromatosis tumor suppressor, ubiquitin-specific proteases 7, 11, 15 and 20, and A-20 to improve their intracellular stability and cellular signaling pathways and finally transformation. Human papillomaviruses (cervical carcinoma, oral cancer and laryngeal cancer); human polyomaviruses (mesotheliomas, brain tumors); Epstein-Barr virus (B-cell lymphoproliferative diseases and nasopharyngeal carcinoma); Kaposi’s Sarcoma Herpesvirus (Kaposi’s Sarcoma and primary effusion lymphomas); hepatitis B (hepatocellular carcinoma (HCC)) cause up to 20% of malignancies around the world

Helicobacter pylori infection and expression of DNA mismatch repair proteins

AIM: To determine the expression of DNA (MMR) proteins, including hMLH1 and hMSH2, in gastric epithelial cells in the patients with or without Helicobacter pylori (H pylori)-infected gastritis